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"I would love some way to get data to really look and see if there is an association between malignancy and tattoos," says Liszewski, "but there's just multiple layers of data that we don't have, and complexities that make it very, very difficult."

Any effort to find out would have to factor in all the different inks used, the differing amount of skin area covered, and the different amounts of time that people had their tattoos.

While an allergic reaction might not be a big deal for a small tattoo, that's not true if someone has a whole sleeve or any other kind of large tattoo. "That can be very, very uncomfortable. It alters your quality of life," says Liszewski. One study found the level of discomfort could be similar to that caused by skin diseases like psoriasis and eczema.

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"If someone is allergic to red, you've got no idea which one they're allergic to. Because individuals who are tattooed, they don't know the ink that was used," he explains. "There is no record keeping because their tattoo artist isn't required to, and tattoo artists may use multiple different inks. It's really hard to tell which ink is at play."

Are Tattoo Inks Safe?

It’s difficult to answer the question of whether tattoo inks are safe, but the evidence available at the moment doesn’t look good – particularly when you address heavy metal content, the threat of mutations and allergens, and even the dangerous affects that inks can have when they migrate into regional lymph nodes.

However, despite the lack of regulation and transparency between consumers and ink providers, people are still racing to get tattoos. Perhaps greater knowledge, more public awareness, strict regulations and testing of inks would improve the safety of the tattoo industry – but only time will tell

A surgery of 300 tattooed people in New York's Central Park found that 6% reported having a chronic reaction — such as itchiness, swelling, scaliness, or raised skin — involving a specific color such as black or red that lasted for more than four months.

Red seems to be the color most often associated with reactions, says Liszewski, but he points out that lots of compounds could be USED to make red

one participant "described a red reaction developing two weeks after a new tattoo, with subsequent development of a similar response in the red ink portion of an 8-year-old tattoo," the researchers wrote.

Are there any long-term health risks?

Sometimes people have reactions to tattoo inks, and these can occur months or years after the ink goes in — although it's not clear why.

Liszewski, who also is a cancer epidemiologist, says it's hard to investigate whether or not tattoo pigments in the body lead to any long-term increased risk of diseases like cancer.

Still, some researchers in Europe are now looking to see if tattoos have any links to immune-related cancers or skin cancers.

Liszewski is not anti-tattoo. He says they can have a lot of personal meaning for people and that body art can be an important way to memorialize "someone who may have died, or an event that they had."

And tattooing is so common nowadays that the researchers studying tattoos, even if they aren't inked, know others who are.

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